Nutr Metab Lond. Published online Dec 6. Author information Article notes Copyright and License information Disclaimer. Corresponding author. Received Oct 17; Accepted Nov This article has been cited by other articles in PMC. Methods Rats were divided in control, 4. Results Running distance and running time increased after acute administration of Conclusion Maximum and not recommended doses of OEP ingested acutely presented stimulating effect on the ability to exercise.
Background Dietary supplements are a great business worldwide. Open field test Open field test was used to assess spontaneous physical activity as previous published by Rosic et al. Exercise Tolerance Test ETT Exercise capacity was determined by graded treadmill exercise test, a method used for detecting exercise intolerance as previous used by our group [ 20 ].
Food and water intake Rats were placed in individual metabolic cages Tecniplast during 48 h for analysis of food and water consumption as previous published by Berger et al. Oxidative stress The levels of lipid peroxidation were determined using the thiobarbituric-acid reactive substances TBARS spectrophotometric assay based on the reaction between malondialdehyde MDA and triobarbituric acid TBA as previous described by our group Leal et al.
Open in a separate window. Spontaneous physical activity Spontaneous physical activity was measured using the open field test Fig. Metabolic parameters and tissue mass OEP is also a well-known dietary supplement for weight loss. Table 1 Effect of OEP supplementation. Liver injury markers Cases of acute hepatitis and liver injury were related to the use of OEP, however the amount of OEP ingestion was reported as unknown or at high doses [ 4 , 5 , 23 ].
Discussion The findings from our study indicate that a single OEP administration stimulated exercise performance Conclusion Our results suggest that doses maximum and not recommended of OEP ingested acutely presents a stimulating effect on the ability to exercise.
Availability of data and material Please contact author for data requests. Competing interests All authors declare that there are no competing interests. Consent for publication Not applicable. References 1. Nutr Metab Insights. N Engl J Med. Am J Gastroenterol. Drug Test Anal. Treatment of human muscle cells with popular dietary supplements increase mitochondrial function and metabolic rate.
Nutr Metab Lond ; 9 Dimethylamylamine: a drug causing positive immunoassay results for amphetamines. J Anal Toxicol. Safety profile of caffeine and 1,3-dimethylamylamine supplementation in healthy men. Hum Exp Toxicol. Abuse liability of the dietary supplement dimethylamylamine. Anal Chem Insights. Identification and quantification of dimethylamylamine in geranium by liquid chromatography tandem mass spectrometry.
Could 1,3 dimethylamylamine DMAA in food supplements have a natural origin? Trend analysis of anonymised pooled urine from portable street urinals in central london identifies variation in the use of novel psychoactive substances.
Clin Toxicol. Physiological and pharmacokinetic effects of oral 1,3-dimethylamylamine administration in men. BMC Pharmacol Toxicol. Anxiogenic effects of chronic exposure to nandrolone decanoate ND at supraphysiological dose in rats: A brief report.
Neuroendocrinol Lett. Exercise training restores the endothelial progenitor cells number and function in hypertension. J Hypertens.
Renal effects and underlying molecular mechanisms of long-term salt content diets in spontaneously hypertensive rats. Curr Pharm Biotechnol. Dig Dis Sci. J Caffeine Res. J Nutr Sci Vitaminol. Spriet LL. Exercise and sport performance with low doses of caffeine. Sports Med. Jornayvaz F, Shulman G. Regulation of mitochondrial biogenesis.
Essays Biochem. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr. Caffeine supplementation modulates oxidative stress markers in the liver of trained rats.
Life Sci Elsevier Inc. J Appl Physiol. Forrester M. Exposures to 1,3-dimethylamylamine-containing products reported to Texas poison centers. Tex Heart Inst J. J Sport Med. When doctors at the hospital suddenly started receiving young and middle-aged adults with liver failure, they knew they had a problem on their hands.
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